Oxford Journals Medicine Evidence-based Compl. and Alt. Medicine Volume 2, Number 1 Pp. 29-32
Recent trends and important developments in propolis research
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences 1113 Sofia, Bulgaria
"For this reason, propolis has become the subject of intense pharmacological and chemical studies for the last 30 years. As a result, much useful knowledge has been gathered. However, it is important to note that in the last decade, the paradigm concerning propolis chemistry radically changed. In the 1960s, propolis was thought to be of very complex, but more or less constant chemistry, like beeswax or bee venom. In the following years, analysis of numerous samples from different geographic regions led to the disclosure that the chemical composition of bee glue is highly variable. This circumstance was soon understood by seasoned chemists, such as Popravko* and Ghisalberti. Nevertheless, most of the scientists studying the biological properties of propolis continued to assume that the term ‘propolis’ was as determinative with respect to chemical composition as the botanical name for a medicinal plant. Numerous studies, carried out with the combined efforts of phytochemists and pharmacologists,led in recent years to the idea that different propolis samples could be completely different in their chemistry and biological activity. "
*Popravko SA. Chemical composition of propolis, its origin and standardization In Harnaj V (Ed.). A Remarkable Hive Product: PROPOLIS 1978;Bucharest Apimondia Publishing House pp. 15–8